The LINACRE Trial

If you have Barrett’s oesophagus and would be interested in the opportunity to participate in a trial looking at an alternative treatment then please read on.

The Oxford Clinical Trials Unit are applying for funding for an exciting new clinical trial for patients with Barrett’s Oesophagus. Barrett’s Oesophagus is currently treated with life long medication to reduce the risk of developing oesophageal cancer. This trial will give patients at various centres in the UK the opportunity to be randomised (by chance) to an alternative treatment or continue long-term medication. The alternative treatment is a day case surgical procedure using key hole surgery to place a LINX device around the oesophagus. The LINX device is used to prevent acid reflux entering into the oesophagus and may reduce symptoms and the requirement for long-term medication. Both groups of patients will be required to be available for follow up appointments, either in person or by telephone/email and to complete questionnaires. It is hoped that the LINX device may provide an alternative strategy in the prevention of oesophageal cancer that is more acceptable to patients.

Please contact us if you would be potentially interested in taking part in the study or if you would like more information.

July 2023 Update - the study is still under review for funding.